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Risks of Concomitant Use or Discontinuation of Cytochrome P450 2D6 Inhibitors The concomitant utilization of tramadol hydrochloride tablets with all cytochrome P450 2D6 inhibitors (e.g., amiodarone, quinidine) might bring about a rise in tramadol plasma stages along with a minimize during the levels of the Energetic metabolite, M1.The effects of co